Vgll3^em1Nakm
Endonuclease-mediated Allele Detail

Summary

• Symbol: Vgll3^em1Nakm
• Name: vestigial like family member 3; endonuclease-mediated mutation 1, Michio Nakaya
• MGI ID: MGI:7524740
• Gene: Vgll3 Location: Chr16:65612143-65663254 bp, + strand Genetic Position: Chr16, 37.34 cM, cytoband C1.3
• Alliance: Vgll3^em1Nakm page

Mutation origin

• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: CRISRP/Cas9 technology deleted most of exon 1 (only the 1st-19th bases of exon 1 are included) and inserted intron-derived sequence between exon 1 and exon 2 generating a stop codon (TAG) at the 37th amino acid. (J:339852)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Vgll3 Mutation: 23 strains or lines available

References

• Original: J:339852 Horii Y, et al., VGLL3 is a mechanosensitive protein that promotes cardiac fibrosis through liquid-liquid phase separation. Nat Commun. 2023 Feb 8;14(1):550
• All: 1 reference(s)