Mlc1^{tm1(tetO)Kftnk}
Targeted Allele Detail

Summary

• Symbol: Mlc1^{tm1(tetO)Kftnk}
• Name: megalencephalic leukoencephalopathy with subcortical cysts 1 homolog (human); targeted mutation 1, Kenji Tanaka
• MGI ID: MGI:7526307
• Synonyms: Mlc1 STOP-tetO, Mlc1 STOPtetO knockin, Mlc1^tm1Rhn
• Gene: Mlc1 Location: Chr15:88840087-88863192 bp, - strand Genetic Position: Chr15, 44.46 cM
• Alliance: Mlc1^{tm1(tetO)Kftnk} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:159353
• Parent Cell Line: CSL3 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Conditional ready, Inducible, No functional change)
• Mutation: Insertion
• Mutation details: The targeting construct inserted a loxP site, FRT site, neo cassette, STOP, FRT site, tetracycline operator (tetO), and loxP site was inserted upstream of the translation initiation site. In situ hybridization confirmed the absence of transcript expression. (J:159353)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mlc1 Mutation: 28 strains or lines available

References

• Original: J:159353 Tanaka KF, et al., Flexible Accelerated STOP Tetracycline Operator-knockin (FAST): a versatile and efficient new gene modulating system. Biol Psychiatry. 2010 Apr 15;67(8):770-3
• All: 3 reference(s)