Mlc1^{tm1.1(tetO)Kftnk}
Targeted Allele Detail

Summary

• Symbol: Mlc1^{tm1.1(tetO)Kftnk}
• Name: megalencephalic leukoencephalopathy with subcortical cysts 1 homolog (human); targeted mutation 1.1, Kenji Tanaka
• MGI ID: MGI:7526308
• Synonyms: Mlc1 tetO, Mlc1^tm1.1Rhn
• Gene: Mlc1 Location: Chr15:88840087-88863192 bp, - strand Genetic Position: Chr15, 44.46 cM
• Alliance: Mlc1^{tm1.1(tetO)Kftnk} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:159353
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S6/SvEvTac and C57BL/6

Mutation description

• Allele Type: Targeted (Inducible)
• Mutation: Insertion
• Mutation details: A mutant allele in which the tetracycline operator (tetO) was inserted upstream of the translation initiation site. Flp-mediated recombination removed the STOP cassette. (J:159353)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mlc1 Mutation: 28 strains or lines available

References

• Original: J:159353 Tanaka KF, et al., Flexible Accelerated STOP Tetracycline Operator-knockin (FAST): a versatile and efficient new gene modulating system. Biol Psychiatry. 2010 Apr 15;67(8):770-3
• All: 3 reference(s)