Oca2^{tm1(cre/ERT2)Mymi}
Targeted Allele Detail

Summary

• Symbol: Oca2^{tm1(cre/ERT2)Mymi}
• Name: oculocutaneous albinism II; targeted mutation 1, Mayumi Ito
• MGI ID: MGI:7526532
• Synonyms: Oca2^creER
• Gene: Oca2 Location: Chr7:55889508-56186266 bp, + strand Genetic Position: Chr7, 33.44 cM
• Alliance: Oca2^{tm1(cre/ERT2)Mymi} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:340038
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Targeted (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Oca2^{tm1(cre/ERT2)Mymi} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Oca2 (MGI:97454)

• Mutation details: The targeting construct was designed to insert p2A-Cre/ERT2 followed by a frt-flanked neo-selection cassette into the mouse Oca2 gene locus. (J:340038)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Oca2 (mouse) Summary of all recombinase alleles driven by Oca2. Comparative matrix view of recombinase activities Alliance mouse Oca2 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Oca2 Mutation: 70 strains or lines available

Notes

MK6 (C57BL/6J) ES cells were used.

References

• Original: J:340038 Sun Q, et al., Dedifferentiation maintains melanocyte stem cells in a dynamic niche. Nature. 2023 Apr;616(7958):774-782
• All: 1 reference(s)