Dvl2^tm1.2Wds
Targeted Allele Detail

Summary

• Symbol: Dvl2^tm1.2Wds
• Name: dishevelled segment polarity protein 2; targeted mutation 1.2, William D Snider
• MGI ID: MGI:7531373
• Gene: Dvl2 Location: Chr11:69891418-69900935 bp, + strand Genetic Position: Chr11, 42.96 cM
• Alliance: Dvl2^tm1.2Wds page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:293794
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: An FRT flanked neo cassette and loxP site were inserted upstream of exon 2 and a loxP site was inserted into exon 15 distal to the stop codon. Flp mediated recombination removed the neo cassette. Cre-mediated recombination removed exon 2 through the coding region of exon 15. (J:293794)

Expression

In Mice Carrying this Mutation:

5 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dvl2 Mutation: 35 strains or lines available

References

• Original: J:293794 Durbin MD, et al., SHROOM3 is downstream of the planar cell polarity pathway and loss-of-function results in congenital heart defects. Dev Biol. 2020 Aug 15;464(2):124-136
• All: 1 reference(s)