Ucp1^em1(cre)Chez
Endonuclease-mediated Allele Detail

Summary

• Symbol: Ucp1^em1(cre)Chez
• Name: uncoupling protein 1 (mitochondrial, proton carrier); endonuclease-mediated mutation 1, Zheng Chen
• MGI ID: MGI:7532766
• Synonyms: Ucp1-iCre
• Gene: Ucp1 Location: Chr8:84016981-84025081 bp, + strand Genetic Position: Chr8, 39.65 cM
• Alliance: Ucp1^em1(cre)Chez page

Mutation origin

• Strain of Origin: Not Applicable

Mutation description

• Allele Type: Endonuclease-mediated (Recombinase)
• Mutation: Insertion
• Ucp1^em1(cre)Chez expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Ucp1 (MGI:98894)

• Mutation details: An IRES-Cre was introduced between the coding sequence of exon 6 and the 3'UTR of the Ucp1 gene. To avoid disrupting the polyA signal of Ucp1 expression, a Neo cassette flanked by frt sites was inserted 300 bp downstream of the 3'UTR. (J:283206)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Ucp1 (mouse) Summary of all recombinase alleles driven by Ucp1. Comparative matrix view of recombinase activities Alliance mouse Ucp1 gene page

Expression

In Mice Carrying this Mutation:

2 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ucp1 Mutation: 51 strains or lines available

References

• Original: J:283206 Li L, et al., Brown adipocytes can display a mammary basal myoepithelial cell phenotype in vivo. Mol Metab. 2017 Oct;6(10):1198-1211
• All: 3 reference(s)