Best3^tm1.1Zhoj
Targeted Allele Detail

Summary

• Symbol: Best3^tm1.1Zhoj
• Name: bestrophin 3; targeted mutation 1.1, Jia-Guo Zhou
• MGI ID: MGI:7532855
• Synonyms: Best3^FL
• Gene: Best3 Location: Chr10:116822219-116860945 bp, + strand Genetic Position: Chr10, 65.0 cM
• Alliance: Best3^tm1.1Zhoj page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:338981
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 3 and an FRT-flanked neo cassette and loxP site were inserted downstream of exon 4 via homologous recombination. Flp-mediated recombination removed the neo cassette. (J:338981)

Disease models

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Best3 Mutation: 37 strains or lines available

References

• Original: J:338981 Zhang TT, et al., Bestrophin3 Deficiency in Vascular Smooth Muscle Cells Activates MEKK2/3-MAPK Signaling to Trigger Spontaneous Aortic Dissection. Circulation. 2023 Aug 15;148(7):589-606
• All: 1 reference(s)