Mirc24^em1Jtm
Endonuclease-mediated Allele Detail

Summary

• Symbol: Mirc24^em1Jtm
• Name: microRNA cluster 24, including Mir351 through Mir322; endonuclease-mediated mutation 1, Joshua T Mendell
• MGI ID: MGI:7537131
• Synonyms: miR322/503^-
• Gene: Mirc24 Location: ChrX:52142132-52143226 bp Genetic Position: ChrX, Syntenic

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intergenic deletion
• Mirc24^em1Jtm involves 2 genes/genome features (Mir503, Mir322) View all
• Mutation details: CRISPR/cas9 mediated recombination using sgRNAs created a 793 bp deletion on mouse Chromosome X (52,142,821-52,143,614; mm10) removing the region including both Mir322 and Mir503. (J:338912)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Mirc24 Mutation: 3 strains or lines available

References

• Original: J:338912 Jones BT, et al., Target-directed microRNA degradation regulates developmental microRNA expression and embryonic growth in mammals. Genes Dev. 2023 Aug 8
• All: 1 reference(s)