Tars3^em1Smoc
Endonuclease-mediated Allele Detail

Summary

• Symbol: Tars3^em1Smoc
• Name: threonyl-tRNA synthetase 3; endonuclease-mediated mutation 1, Shanghai Model Organisms
• MGI ID: MGI:7539368
• Synonyms: Tarsl2^-, Tarsl2^em1Smoc
• Gene: Tars3 Location: Chr7:65294646-65341839 bp, + strand Genetic Position: Chr7, 35.23 cM
• Alliance: Tars3^em1Smoc page

Mutation origin

• Strain of Origin: C57BL/6JSmoc

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 technology using gRNAs 5-ACCCTTGGTATCCCGAGAACTGG-3 AND 5-AGACAACATTAATTGTATACGGG-3 deleted exon 3 and resulted in premature termination of mRNA translation at Val114. (J:341137)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tars3 Mutation: 49 strains or lines available

References

• Original: J:341137 Zeng QY, et al., Loss of threonyl-tRNA synthetase-like protein Tarsl2 has little impact on protein synthesis but affects mouse development. J Biol Chem. 2023 May;299(5):104704
• All: 1 reference(s)