Tars1^em1Cya
Endonuclease-mediated Allele Detail

Summary

• Symbol: Tars1^em1Cya
• Name: threonyl-tRNA synthetase 1; endonuclease-mediated mutation 1, Cyagen Biosciences
• MGI ID: MGI:7539369
• Synonyms: Tars^em1C, Tars^em1cyagen
• Gene: Tars1 Location: Chr15:11383749-11399744 bp, - strand Genetic Position: Chr15, 5.6 cM
• Alliance: Tars1^em1Cya page

Mutation origin

• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 technology using gRNAs 5-TCTCTTAGGATGCCCTCCTAAGGAGG-3 and 5-GCTTGTGACTGACTAAGATCAGG-3 deleted exons 3-11. (J:341137)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tars1 Mutation: 25 strains or lines available

References

• Original: J:341137 Zeng QY, et al., Loss of threonyl-tRNA synthetase-like protein Tarsl2 has little impact on protein synthesis but affects mouse development. J Biol Chem. 2023 May;299(5):104704
• All: 1 reference(s)