Iqch^em2Alfon
Endonuclease-mediated Allele Detail

Summary

• Symbol: Iqch^em2Alfon
• Name: IQ motif containing H; endonuclease-mediated mutation 2, Alfonso Gutierrez-Adan
• MGI ID: MGI:7539523
• Synonyms: Iqch^mu7
• Gene: Iqch Location: Chr9:63328737-63509775 bp, - strand Genetic Position: Chr9, 34.08 cM, cytoband D
• Alliance: Iqch^em2Alfon page

Mutation origin

• Strain of Origin: (C57BL/6 x CBA)F1

Mutation description

• Allele Type: Endonuclease-mediated (Not Applicable)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 technology generated a 19 bp deletion in exon 19. This is predicted to produce a protein consisting of 978 amino acids instead of the 1071 amino acids in the wild-type protein, lacking the DNA binding domain. Western blot analysis showed that the wild-type 1071 amino acid protein is absent in testes of homozygotes. (J:338977)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Iqch Mutation: 53 strains or lines available

References

• Original: J:338977 Navarrete-Lopez P, et al., An ancient testis-specific IQ motif-containing H gene regulates specific transcript isoform expression during spermatogenesis. Development. 2023 Apr 1;150(7)
• All: 1 reference(s)