Mirc35^tm1.1Pern
Targeted Allele Detail

Summary

• Symbol: Mirc35^tm1.1Pern
• Name: microRNA cluster 35, including Mir182 through Mir183; targeted mutation 1.1, Patrik Ernfors
• MGI ID: MGI:7539557
• Synonyms: miR-183/96/182^fl
• Gene: Mirc35 Location: Chr6:30165917-30169736 bp Genetic Position: Chr6, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:243640
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: The targeting construct inserted a loxP upstream of Mir183 and an F3-flanked neomycin resistance cassette with a 3' loxP site downstream of Mir182. Flp-mediated recombination removed the selection cassette and left the microRNA cluster floxed. (J:243640)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mirc35 Mutation: 4 strains or lines available

References

• Original: J:243640 Peng C, et al., miR-183 cluster scales mechanical pain sensitivity by regulating basal and neuropathic pain genes. Science. 2017 Jun 16;356(6343):1168-1171
• All: 3 reference(s)