Ntrk2^{tm1.1(cre/ERT2)Pern}
Targeted Allele Detail

Summary

• Symbol: Ntrk2^{tm1.1(cre/ERT2)Pern}
• Name: neurotrophic tyrosine kinase, receptor, type 2; targeted mutation 1.1, Patrik Ernfors
• MGI ID: MGI:7539562
• Synonyms: TrkB-CreERT2
• Gene: Ntrk2 Location: Chr13:58954383-59281784 bp, + strand Genetic Position: Chr13, 31.2 cM
• Alliance: Ntrk2^{tm1.1(cre/ERT2)Pern} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:270955
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Ntrk2^{tm1.1(cre/ERT2)Pern} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Ntrk2 (MGI:97384)

• Mutation details: The targeting construct inserted the inducible cre fusion recombinase (cre/ERT2) into the 3'UTR. Flp-mediated recombination removed the selection cassette. (J:270955)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Ntrk2 (mouse) Summary of all recombinase alleles driven by Ntrk2. Alliance mouse Ntrk2 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ntrk2 Mutation: 66 strains or lines available

References

• Original: J:270955 Peng C, et al., Termination of cell-type specification gene programs by the miR-183 cluster determines the population sizes of low-threshold mechanosensitive neurons. Development. 2018 Sep 25;145(18):dev165613
• All: 1 reference(s)