Eif4e1b^em2Dean
Endonuclease-mediated Allele Detail

Summary

• Symbol: Eif4e1b^em2Dean
• Name: eukaryotic translation initiation factor 4E family member 1B; endonuclease-mediated mutation 2, Jurrien Dean
• MGI ID: MGI:7539705
• Synonyms: delta411
• Gene: Eif4e1b Location: Chr13:54931811-54936272 bp, + strand Genetic Position: Chr13, 29.39 cM
• Alliance: Eif4e1b^em2Dean page

Mutation origin

• Strain of Origin: (C57BL/6 x DBA/2)F1

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• CRISPR/Cas9 technology generated a 411 bp deletion. (J:337681)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Eif4e1b Mutation: 25 strains or lines available

References

• Original: J:337681 Yang G, et al., Germ cell-specific eIF4E1b regulates maternal mRNA translation to ensure zygotic genome activation. Genes Dev. 2023 May 1;37(9-10):418-431
• All: 1 reference(s)