Tacr1^{tm1.1(cre/ERT2)Ddg}
Targeted Allele Detail

Summary

• Symbol: Tacr1^{tm1.1(cre/ERT2)Ddg}
• Name: tachykinin receptor 1; targeted mutation 1.1, David D Ginty
• MGI ID: MGI:7539708
• Synonyms: Tacr1^CreERT2
• Gene: Tacr1 Location: Chr6:82379315-82537085 bp, + strand Genetic Position: Chr6, 35.94 cM, cytoband D1
• Alliance: Tacr1^{tm1.1(cre/ERT2)Ddg} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:297417
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Tacr1^{tm1.1(cre/ERT2)Ddg} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Tacr1 (MGI:98475)

• Mutation details: A Cre recombinase-estrogen receptor T2 (CreERT2) fusion cassettes were introduced via homologous recombination into the Tacr1 genes, replacing the first coding ATG. The neomycin selection cassette was removed by recombination. (J:297417)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Tacr1 (mouse) Summary of all recombinase alleles driven by Tacr1. Comparative matrix view of recombinase activities Alliance mouse Tacr1 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Tacr1 Mutation: 40 strains or lines available

References

• Original: J:297417 Choi S, et al., Parallel ascending spinal pathways for affective touch and pain. Nature. 2020 Nov;587(7833):258-263
• All: 2 reference(s)