Tnni3k^A
Spontaneous Allele Detail

Summary

• Symbol: Tnni3k^A
• Name: TNNI3 interacting kinase; A
• MGI ID: MGI:7540645
• Synonyms: B allele, Hrtfm2^C57BL/6J, Hrtfm8^AKR/J
• Gene: Tnni3k Location: Chr3:154491928-154761044 bp, - strand Genetic Position: Chr3, 79.32 cM
• Alliance: Tnni3k^A page

Mutation origin

• Strain of Origin: Not Applicable

Mutation description

• Allele Type: Spontaneous (Not Applicable)
• Mutation: Not Applicable
• Mutation details: This naturally occurring strain-specific allele is the major allele and represents the G variant of coding SNP rs30712233 and the T variant of splice region SNP rs49812611 and is found in the reference C57BL/6J strain and in AKR/J and 129S1/SvImJ and others. These variants are A and C, respectively, in DBA/2J, C3H/HeJ and BALB/cByJ and others. The rs30712233-G variant (c.1976C) codes for a threonine codon at 659 (ACT) (p.T659) and the rs49812611-T splicing variant at the 9th nucleotide of intron 19 (c.1875+9A) enables normal splicing. (J:154116, J:339644)
• Inheritance: Dominant

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tnni3k Mutation: 47 strains or lines available

References

• Original: J:154116 Wheeler FC, et al., Tnni3k modifies disease progression in murine models of cardiomyopathy. PLoS Genet. 2009 Sep;5(9):e1000647
• All: 2 reference(s)