Tvp23b^m1Btlr
Chemically induced Allele Detail

Summary

• Symbol: Tvp23b^m1Btlr
• Name: trans-golgi network vesicle protein 23B; mutation 1, Bruce Beutler
• MGI ID: MGI:7541038
• Synonyms: Tvp23b^chipotle
• Gene: Tvp23b Location: Chr11:62770281-62786012 bp, + strand Genetic Position: Chr11, 38.81 cM, cytoband B2
• Alliance: Tvp23b^m1Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU) (Null/knockout)
• Mutation: Single point mutation
• Mutation details: ENU mutagenesis inducted a point mutation in a putative donor splice site mutation (G to T transversion of the third nucleotide of intron 1). Exon 1 skipping result in a 141 bp deletion and loss of the start codon. (J:340685)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tvp23b Mutation: 17 strains or lines available

References

• Original: J:340685 Song R, et al., Trans-Golgi protein TVP23B regulates host-microbe interactions via Paneth cell homeostasis and Goblet cell glycosylation. Nat Commun. 2023 Jun 20;14(1):3652
• All: 1 reference(s)