Dnali1^em1Yxc
Endonuclease-mediated Allele Detail

Summary

• Symbol: Dnali1^em1Yxc
• Name: dynein, axonemal, light intermediate polypeptide 1; endonuclease-mediated mutation 1, Yunxia Cao
• MGI ID: MGI:7541056
• Gene: Dnali1 Location: Chr4:124949131-124959443 bp, - strand Genetic Position: Chr4, 57.99 cM, cytoband D
• Alliance: Dnali1^em1Yxc page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• CRISPR-targeting deleted exons 3 through 5. (J:340653)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dnali1 Mutation: 14 strains or lines available

References

• Original: J:340653 Wu H, et al., DNALI1 deficiency causes male infertility with severe asthenozoospermia in humans and mice by disrupting the assembly of the flagellar inner dynein arms and fibrous sheath. Cell Death Dis. 2023 Feb 15;14(2):127
• All: 1 reference(s)