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Glipr1l1em1Mkob
Endonuclease-mediated Allele Detail
Summary
Symbol: Glipr1l1em1Mkob
Name: GLI pathogenesis-related 1 like 1; endonuclease-mediated mutation 1, Moira K O'Bryan
MGI ID: MGI:7541080
Gene: Glipr1l1  Location: Chr10:111896094-111914415 bp, + strand  Genetic Position: Chr10, 60.07 cM, cytoband D1
Alliance: Glipr1l1em1Mkob page
Mutation
origin
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Endonuclease-mediated (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsCRISPR/Cas9 technology generated a 7-bp deletion (ACTATCA) in exon 1, which is predicted to result in a premature stop codon in exon 1 and a frame-shift mutation. qPCR analysis shows a 92% reduction in mRNA levels in isolated testis and germ cells from homozygotes. Immunofluorescent labeling confirmed absence of protein in sperm. (J:290694)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Glipr1l1 Mutation:  23 strains or lines available
References
Original:  J:290694 Gaikwad AS, et al., GLIPR1L1 is an IZUMO-binding protein required for optimal fertilization in the mouse. BMC Biol. 2019 Oct 31;17(1):86
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory