Carnmt1^em2Yshk
Endonuclease-mediated Allele Detail

Summary

• Symbol: Carnmt1^em2Yshk
• Name: carnosine N-methyltransferase 1; endonuclease-mediated mutation 2, Yoichi Shinkai
• MGI ID: MGI:7541268
• Synonyms: Carnmt1^deltaCat, Carnmt1^G199/201R
• Gene: Carnmt1 Location: Chr19:18648128-18684564 bp, + strand Genetic Position: Chr19, 13.18 cM, cytoband E1
• Alliance: Carnmt1^em2Yshk page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR-targeting deleted the sequence encoding amino acids glycine 199 through arginine 201 to generate a catalytically inactive protein. (J:341536)

Expression

In Mice Carrying this Mutation:

2 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Carnmt1 Mutation: 61 strains or lines available

References

• Original: J:341536 Shimazu T, et al., Histidine N1-position-specific methyltransferase CARNMT1 targets C3H zinc finger proteins and modulates RNA metabolism. Genes Dev. 2023 Aug 1;37(15-16):724-742
• All: 1 reference(s)