Slc39a8^tm1.1Brvo
Targeted Allele Detail

Summary

• Symbol: Slc39a8^tm1.1Brvo
• Name: solute carrier family 39 (metal ion transporter), member 8; targeted mutation 1.1, Bruno Vogt
• MGI ID: MGI:7541328
• Synonyms: ZIP8 A393T, ZIP8KI
• Gene: Slc39a8 Location: Chr3:135531040-135594333 bp, + strand Genetic Position: Chr3, 63.04 cM
• Alliance: Slc39a8^tm1.1Brvo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:341571
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Humanized sequence)
• Mutation: Single point mutation
• Mutation details: Alanine codon 393 (GCT) in exon 7 was changed to threonine (ACT) (p.A393T) and an FRT site flanked neomycin resistance gene cassette was inserted into intron 8. The neo cassette was removed through subsequent Flp-mediated recombination. The mutation is the equivalent of the human p.A391T mutation (SNP rs13107325) associated with numerous traits, including reduced arterial blood pressure, increased body mass index and hyperlipidemia. (J:341571)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Slc39a8 Mutation: 43 strains or lines available

References

• Original: J:341571 Verouti SN, et al., The Allelic Variant A391T of Metal Ion Transporter ZIP8 (SLC39A8) Leads to Hypotension and Enhanced Insulin Resistance. Front Physiol. 2022;13:912277
• All: 1 reference(s)