Gm26330^em1Liuq
Endonuclease-mediated Allele Detail

Summary

• Symbol: Gm26330^em1Liuq
• Name: predicted gene, 26330; endonuclease-mediated mutation 1, Liuqing Yang
• MGI ID: MGI:7543240
• Synonyms: Snord46^G11A
• Gene: Gm26330 Location: Chr4:117012383-117012486 bp, - strand Genetic Position: Chr4, Syntenic
• Alliance: Gm26330^em1Liuq page

Mutation origin

• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Endonuclease-mediated (Not Applicable)
• Mutation: Single point mutation
• Mutation details: A point mutation (r.11G>A, GRCm39:chr4:117012474C>T) was created using an sgRNA and an ssODN template with CRISPR/Cas9 technology. The mutated residue is involved in binding to IL15 protein. (J:341056)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gm26330 Mutation: 0 strains or lines available

References

• Original: J:341056 Zhang Y, et al., Molecular mechanisms of snoRNA-IL-15 crosstalk in adipocyte lipolysis and NK cell rejuvenation. Cell Metab. 2023 Aug 8;35(8):1457-1473.e13
• All: 1 reference(s)