Mcemp1^em1Jngj
Endonuclease-mediated Allele Detail

Summary

• Symbol: Mcemp1^em1Jngj
• Name: mast cell expressed membrane protein 1; endonuclease-mediated mutation 1, Jae U Jung
• MGI ID: MGI:7543594
• Gene: Mcemp1 Location: Chr8:3715754-3718916 bp, + strand Genetic Position: Chr8, 1.92 cM, cytoband A1
• Alliance: Mcemp1^em1Jngj page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• CRISPR-targeting of exon 1 deleted 11 bp resulting in a frameshift and premature termination. (J:335318)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mcemp1 Mutation: 12 strains or lines available

References

• Original: J:335318 Choi YJ, et al., Lung-specific MCEMP1 functions as an adaptor for KIT to promote SCF-mediated mast cell proliferation. Nat Commun. 2023 Apr 11;14(1):2045
• All: 1 reference(s)