Degs2^tm1Akih
Targeted Allele Detail

Summary

• Symbol: Degs2^tm1Akih
• Name: delta 4-desaturase, sphingolipid 2; targeted mutation 1, Akio Kihara
• MGI ID: MGI:7543601
• Gene: Degs2 Location: Chr12:108653051-108668561 bp, - strand Genetic Position: Chr12, 59.46 cM
• Alliance: Degs2^tm1Akih page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:335270
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• The targeting construct introduced a neomycin resistance cassette into exon 2. (J:335270)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Degs2 Mutation: 17 strains or lines available

References

• Original: J:335270 Ota A, et al., Bifunctional DEGS2 has higher hydroxylase activity toward substrates with very-long-chain fatty acids in the production of phytosphingosine ceramides. J Biol Chem. 2023 Apr;299(4):104603
• All: 1 reference(s)