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Gt(ROSA)26Sortm1(Mib1*V943F)Jlp
Targeted Allele Detail
Summary
Symbol: Gt(ROSA)26Sortm1(Mib1*V943F)Jlp
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Jose de la Pompa
MGI ID: MGI:7543648
Synonyms: R26MIB1V943F
Gene: Gt(ROSA)26Sor  Location: Chr6:113044389-113054205 bp, - strand  Genetic Position: Chr6, 52.73 cM
Alliance: Gt(ROSA)26Sortm1(Mib1*V943F)Jlp page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:338889
Parent Cell Line:  G4 (ES Cell)
Strain of Origin:  (129S6/SvEvTac x C57BL/6NCrl)F1
Mutation
description
Allele Type:    Targeted (Conditional ready, Inserted expressed sequence)
Mutation:    Insertion
 
Mutation detailsThe following elements were inserted in an intron of the gene: a loxP site, a neomycin resistance gene and STOP cassette, a second loxP site, sequence coding for an HA tag in-frame with the coding sequence for Mib1 with a p.V943F mutation, IRES sequence and the EGFP fluorescent reporter gene. The inserted Mib1 and EGFP genes will only be expressed after Cre-mediated removal of the neo-STOP cassette. (J:338889)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gt(ROSA)26Sor Mutation:  992 strains or lines available
References
Original:  J:338889 Siguero-Alvarez M, et al., A Human Hereditary Cardiomyopathy Shares a Genetic Substrate With Bicuspid Aortic Valve. Circulation. 2023 Jan 3;147(1):47-65
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory