Elmo2^tm1.1Jfco
Targeted Allele Detail

Summary

• Symbol: Elmo2^tm1.1Jfco
• Name: engulfment and cell motility 2; targeted mutation 1.1, Jean-Francois Cote
• MGI ID: MGI:7544996
• Synonyms: Elmo2^RBD
• Gene: Elmo2 Location: Chr2:165129951-165168399 bp, - strand Genetic Position: Chr2, 85.53 cM
• Alliance: Elmo2^tm1.1Jfco page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:331473
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutations: Insertion, Single point mutation
• Mutation details: The targeting construct replaced exon 3 with one containing the mutation responsible for the amino acid substitution of leucine to alanine at position 43 (L43A). This mutation abolishes the function of the RAS-Binding domain. Flp-mediated recombination removed the FRT-flanked neomycin resistance cassette. (J:331473)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Elmo2 Mutation: 37 strains or lines available

References

• Original: J:331473 Tran V, et al., Biasing the conformation of ELMO2 reveals that myoblast fusion can be exploited to improve muscle regeneration. Nat Commun. 2022 Nov 18;13(1):7077
• All: 1 reference(s)