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Elac2em1Afi
Endonuclease-mediated Allele Detail
Summary
Symbol: Elac2em1Afi
Name: elaC ribonuclease Z 2; endonuclease-mediated mutation 1, Aleksandra Filipovska
MGI ID: MGI:7545038
Synonyms: ELAC2 A537T
Gene: Elac2  Location: Chr11:64869864-64892895 bp, + strand  Genetic Position: Chr11, 40.42 cM, cytoband B3
Alliance: Elac2em1Afi page
Mutation
origin
Strain of Origin:  C57BL/6N
Mutation
description
Allele Type:    Endonuclease-mediated (Humanized sequence)
Mutation:    Single point mutation
 
Mutation detailsAlanine codon 537 (GCT) in exon 17 was changed to threonine (ACT) (p.A537T) using an sgRNA and an ssODN template with CRISPR/Cas9. The mutation is the equivalent of the human p.A541T mutation associated with prostate cancer predisposition. (J:336403)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 3 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Elac2 Mutation:  40 strains or lines available
References
Original:  J:336403 Stentenbach M, et al., Multi-omic profiling reveals an RNA processing rheostat that predisposes to prostate cancer. EMBO Mol Med. 2023 Jun 7;15(6):e17463
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory