Elac2^em1Afi
Endonuclease-mediated Allele Detail

Summary

• Symbol: Elac2^em1Afi
• Name: elaC ribonuclease Z 2; endonuclease-mediated mutation 1, Aleksandra Filipovska
• MGI ID: MGI:7545038
• Synonyms: ELAC2 A537T
• Gene: Elac2 Location: Chr11:64869864-64892895 bp, + strand Genetic Position: Chr11, 40.42 cM, cytoband B3
• Alliance: Elac2^em1Afi page

Mutation origin

• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Endonuclease-mediated (Humanized sequence)
• Mutation: Single point mutation
• Mutation details: Alanine codon 537 (GCT) in exon 17 was changed to threonine (ACT) (p.A537T) using an sgRNA and an ssODN template with CRISPR/Cas9. The mutation is the equivalent of the human p.A541T mutation associated with prostate cancer predisposition. (J:336403)

Expression

In Mice Carrying this Mutation:	2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Elac2 Mutation: 40 strains or lines available

References

• Original: J:336403 Stentenbach M, et al., Multi-omic profiling reveals an RNA processing rheostat that predisposes to prostate cancer. EMBO Mol Med. 2023 Jun 7;15(6):e17463
• All: 1 reference(s)