Lepr^db-Nokl
Spontaneous Allele Detail

Summary

• Symbol: Lepr^db-Nokl
• Name: leptin receptor; diabetes Nora Kloeting
• MGI ID: MGI:7545269
• Synonyms: Lepr^L536Hfs*6, Lepr^{L536Hfs*6-1NKB}
• Gene: Lepr Location: Chr4:101574601-101672549 bp, + strand Genetic Position: Chr4, 46.96 cM
• Alliance: Lepr^db-Nokl page

Mutation origin

• Strain of Origin: C57BL/6NCrl

Mutation description

• Allele Type: Spontaneous (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: This spontaneous mutation involves the deletion of a single nucleotide in exon 11 (GRCm39:chr4:101628503delT) in the cytokine receptor homology 2 (CRH2) leptin-binding domain of the encoded peptide, which causes a frameshift and premature stop codon (p.L536Hfs*6). (J:313303)

Disease models

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lepr Mutation: 122 strains or lines available

References

• Original: J:313303 Berger C, et al., A novel compound heterozygous leptin receptor mutation causes more severe obesity than in Lepr(db/db) mice. J Lipid Res. 2021 Aug 11;62:100105
• All: 1 reference(s)