Fgf21^em1(cre)Mpot
Endonuclease-mediated Allele Detail

Summary

• Symbol: Fgf21^em1(cre)Mpot
• Name: fibroblast growth factor 21; endonuclease-mediated mutation 1, Matthew J Potthoff
• MGI ID: MGI:7546790
• Synonyms: FGF21-P2A-Cre
• Gene: Fgf21 Location: Chr7:45263314-45264914 bp, - strand Genetic Position: Chr7, 29.38 cM, cytoband B2
• Alliance: Fgf21^em1(cre)Mpot page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Recombinase)
• Mutation: Insertion
• Fgf21^em1(cre)Mpot expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Fgf21 (MGI:1861377)

• Mutation details: Using CRISPR/Cas9 technology, a viral 2A oligopeptide and a CRE recombinase gene were inserted immediately downstream of the Fgf21 stop codon. (J:342128)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Fgf21 (mouse) Summary of all recombinase alleles driven by Fgf21. Comparative matrix view of recombinase activities Alliance mouse Fgf21 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fgf21 Mutation: 22 strains or lines available

References

• Original: J:342128 Zhou B, et al., Central FGF21 production regulates memory but not peripheral metabolism. Cell Rep. 2022 Aug 23;40(8):111239
• All: 2 reference(s)