Nps^tm1.1Rkr
Targeted Allele Detail

Summary

• Symbol: Nps^tm1.1Rkr
• Name: neuropeptide S; targeted mutation 1.1, Rainer K Reinscheid
• MGI ID: MGI:7547096
• Gene: Nps Location: Chr7:134870348-134874671 bp, + strand Genetic Position: Chr7, 81.27 cM
• Alliance: Nps^tm1.1Rkr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:342064
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 3 and a PGK-neo cassette and loxP site were inserted downstream of exon 3 via homologous recombination. Cre mediated recombination removed exon 3 and the neo cassette. Extracts from brains of homozygous mice contain virtually no NPS-like immunoreactive material. (J:342064)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nps Mutation: 15 strains or lines available

References

• Original: J:342064 Liu X, et al., Neuropeptide S precursor knockout mice display memory and arousal deficits. Eur J Neurosci. 2017 Jul;46(1):1689-1700
• All: 2 reference(s)