Sell^{em1(cre/ERT2)Mnz}
Endonuclease-mediated Allele Detail

Summary

• Symbol: Sell^{em1(cre/ERT2)Mnz}
• Name: selectin, lymphocyte; endonuclease-mediated mutation 1, Michel C Nussenzweig
• MGI ID: MGI:7548487
• Synonyms: Sell^IRES-CreERT2
• Gene: Sell Location: Chr1:163889556-163908354 bp, + strand Genetic Position: Chr1, 71.37 cM
• Alliance: Sell^{em1(cre/ERT2)Mnz} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:342405
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Sell^{em1(cre/ERT2)Mnz} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Sell (MGI:98279)

• Using CRISPR/Cas9 technology IRES-iCreERT2 cassette was inserted in exon 8 of the Sell gene. (J:342405)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Sell (mouse) Summary of all recombinase alleles driven by Sell. Alliance mouse Sell gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sell Mutation: 42 strains or lines available

Notes

Lentiviral gene trap injected into zygotes.

References

• Original: J:342405 Merkenschlager J, et al., Continually recruited naive T cells contribute to the follicular helper and regulatory T cell pools in germinal centers. Nat Commun. 2023 Oct 31;14(1):6944
• All: 1 reference(s)