Msi2^{tm1.1(cre/ERT2)Reya}
Targeted Allele Detail

Summary

• Symbol: Msi2^{tm1.1(cre/ERT2)Reya}
• Name: musashi RNA-binding protein 2; targeted mutation 1.1, Tannishtha Reya
• MGI ID: MGI:7548734
• Synonyms: Msi2^CreERT2
• Gene: Msi2 Location: Chr11:88230208-88609197 bp, - strand Genetic Position: Chr11, 52.4 cM, cytoband B5-C
• Alliance: Msi2^{tm1.1(cre/ERT2)Reya} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:342146
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Msi2^{tm1.1(cre/ERT2)Reya} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Msi2 (MGI:1923876)

• Mutation details: A CreERT2-cassette was integrated into the start codon of the Msi2 locus exon1 via homologous recombination in ES cells. (J:342146)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Msi2 (mouse) Summary of all recombinase alleles driven by Msi2. Comparative matrix view of recombinase activities Alliance mouse Msi2 gene page

Tumor Data

List all tumor models in MMHCdb carrying Msi2^{tm1.1(cre/ERT2)Reya}

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Msi2 Mutation: 781 strains or lines available

References

• Original: J:342146 Rajbhandari N, et al., Single-cell mapping identifies MSI(+) cells as a common origin for diverse subtypes of pancreatic cancer. Cancer Cell. 2023 Sep 25
• All: 1 reference(s)