Crygc^M2J
Spontaneous Allele Detail

Summary

• Symbol: Crygc^M2J
• Name: crystallin, gamma C; mutation 2 Jackson
• MGI ID: MGI:7549103
• Synonyms: Crygc^dup
• Gene: Crygc Location: Chr1:65110684-65112691 bp, - strand Genetic Position: Chr1, 32.81 cM
• Alliance: Crygc^M2J page

Mutation origin

• Strain of Origin: B6.A-Crygb^S11R/BocJ

Mutation description

• Allele Type: Spontaneous (Hypomorph)
• Mutations: Insertion, Other
• Mutation details: This spontaneous 5bp duplication, c.409_413dup, is predicted to result in a frameshift after the third greek key motif, translation of a stretch of aberrant sequence, and premature termination before the fourth greek key motif (J:341260)
• Inheritance: Semidominant

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Crygc Mutation: 13 strains or lines available

References

• Original: J:341260 Minogue PJ, et al., A crystallin mutant cataract with mineral deposits. J Biol Chem. 2023 Jun 17;299(8):104935
• All: 1 reference(s)