Cdkn2a^{em1.1(cre/ERT2)Jvd}
Endonuclease-mediated Allele Detail

Summary

• Symbol: Cdkn2a^{em1.1(cre/ERT2)Jvd}
• Name: cyclin dependent kinase inhibitor 2A; endonuclease-mediated mutation 1.1, Jan MA van Deursen
• MGI ID: MGI:7561499
• Synonyms: p16-EF/CreER^T2
• Gene: Cdkn2a Location: Chr4:89192710-89212856 bp, - strand Genetic Position: Chr4, 42.15 cM, cytoband C3-C6
• Alliance: Cdkn2a^{em1.1(cre/ERT2)Jvd} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:342853
• Parent Cell Line: TL1/TL-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Endonuclease-mediated (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Cdkn2a^{em1.1(cre/ERT2)Jvd} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Cdkn2a (MGI:104738)

• Mutation details: TALEN-targeting inserted the inducible recombinase fusion gene (cre/ERT2) into exon 1. Flp-mediated recombination removed the FRT-flanked selection cassette. (J:342853)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Cdkn2a (mouse) Summary of all recombinase alleles driven by Cdkn2a. Alliance mouse Cdkn2a gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cdkn2a Mutation: 67 strains or lines available

References

• Original: J:342853 Cherry C, et al., Transfer learning in a biomaterial fibrosis model identifies in vivo senescence heterogeneity and contributions to vascularization and matrix production across species and diverse pathologies. Geroscience. 2023;45(4):2559-2587
• All: 1 reference(s)