Relb^tm1.1Alex
Targeted Allele Detail

Summary

• Symbol: Relb^tm1.1Alex
• Name: avian reticuloendotheliosis viral (v-rel) oncogene related B; targeted mutation 1.1, Alexander Hoffmann
• MGI ID: MGI:7561998
• Synonyms: Relb^Db
• Gene: Relb Location: Chr7:19340142-19363352 bp, - strand Genetic Position: Chr7, 9.93 cM
• Alliance: Relb^tm1.1Alex page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:101977
• Parent Cell Line: iTL IC1 (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutation: Nucleotide substitutions
• Mutation details: The targeting vector is designed to insert three point mutations (R117A / Y120A / E123A) in the 5' region of the gene. The mutations result in loss of B-site specific DNA binding. The targeting construct also included an FRT-flanked neomycin (neo) cassette Flp-mediated recombination removed the neo cassette. (J:101977)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Relb Mutation: 33 strains or lines available

References

• Original: J:101977 The Jackson Laboratory, Information obtained from The Jackson Laboratory, Bar Harbor, ME. Unpublished. 2005-2017
• All: 1 reference(s)