Gt(ROSA)26Sor^{tm1(CD68-cre/ERT2)Drg}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm1(CD68-cre/ERT2)Drg}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, David Greaves
• MGI ID: MGI:7562289
• Synonyms: hCD68-CreERT2
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm1(CD68-cre/ERT2)Drg} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:335680
• Parent Cell Line: JM8.F6 (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Recombinase)
• Mutation: Insertion
• Gt(ROSA)26Sor^{tm1(CD68-cre/ERT2)Drg} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Cd68 (MGI:88342)

• Mutation details: The targeting vector contains a human CD68 promoter (consisting of CD68 5'; flanking sequence with the 83 bp first intron [IVS-1] of the CD68 gene), a Cre recombinase/ERT2 fusion, an IRES, and polyA sequence. The vector is flanked by PhiC31 attP sites and contains a promoterless neomycin cassette upstream of the CD68 promoter. (J:335680)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Cd68 (mouse) Summary of all recombinase alleles driven by Cd68. Alliance mouse Cd68 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 993 strains or lines available

References

• Original: J:335680 Rumianek AN, et al., A Human CD68 Promoter-Driven Inducible Cre-Recombinase Mouse Line Allows Specific Targeting of Tissue Resident Macrophages. Front Immunol. 2022;13:918636
• All: 1 reference(s)