Api5^em1Cad
Endonuclease-mediated Allele Detail

Summary

• Symbol: Api5^em1Cad
• Name: apoptosis inhibitor 5; endonuclease-mediated mutation 1, Ken Cadwell
• MGI ID: MGI:7563901
• Gene: Api5 Location: Chr2:94242073-94268490 bp, - strand Genetic Position: Chr2, 51.84 cM
• Alliance: Api5^em1Cad page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Insertion
• Mutation details: CRISPR/cas9 mediated recombination in zygotes from a cross of females homozygous for Atg16l1^{tm1c(EUCOMM)Wtsi} and males homozygous for Atg16l1^{tm1c(EUCOMM)Wtsi} and carrying Tg(Vil1-cre)997Gum> created a 2 nucleotide insertion of AT after the third codon resulting in a frameshift and premature stop at amino acid position 30. (J:340266)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Api5 Mutation: 33 strains or lines available

References

• Original: J:340266 Matsuzawa-Ishimoto Y, et al., The gammadelta IEL effector API5 masks genetic susceptibility to Paneth cell death. Nature. 2022 Oct;610(7932):547-554
• All: 1 reference(s)