Tg(C9orf72_i3)101Lutzy
Transgene Detail

Summary

• Symbol: Tg(C9orf72_i3)101Lutzy
• Name: transgene insertion 101, Cathleen Lutz
• MGI ID: MGI:7564002
• Transgene: Tg(C9orf72_i3)101Lutzy Location: unknown Genetic Position: ChrUN, Syntenic
• Alliance: Tg(C9orf72_i3)101Lutzy page

Transgene origin

• Strain of Origin: FVB/NJ

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(C9orf72_i3)101Lutzy expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  C9orf72 (203228)

  C9orf72

  (MGI:1920455)

  contraction limited to 100-750 GGGGCC repeats

• Mutation details: The transgenic construct contains a bacterial artificial chromosome (BAC) clone derived from fibroblasts of a patient with amyotrophic lateral sclerosis (ALS), carrying the human chromosome 9 open reading frame 72 gene (C9orf72) with a hexanucleotide repeat expansion (GGGGCC) in the intron between the alternatively-spliced non-coding first exons 1a and 1b. Sequence isolated from the BAC included a ~166 kbp sequence (~36 kbp human C9orf72 genomic sequence, with ~110 kbp upstream and ~20 kbp downstream sequences). Upon amplification of different BAC subclones in bacteria, the repeat expansion underwent contraction in some clones. This BAC subclone is limited to a contraction of 100-750 GGGGCC repeats. At least 3 copies of the transgene integrated in tandem (segregating together); each copy harboring 780, 530 and 170 GGGGCC repeats, as determined by southern blot. (J:101977)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:101977 The Jackson Laboratory, Information obtained from The Jackson Laboratory, Bar Harbor, ME. Unpublished. 2005-2017
• All: 1 reference(s)