Mir10b^em1Rosay
Endonuclease-mediated Allele Detail

Summary

• Symbol: Mir10b^em1Rosay
• Name: microRNA 10b; endonuclease-mediated mutation 1, Kenton M Sanders and Seungil Ro
• MGI ID: MGI:7564075
• Gene: Mir10b Location: Chr2:74556414-74556481 bp, + strand Genetic Position: Chr2, 44.13 cM
• Alliance: Mir10b^em1Rosay page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR-Mb3Cas12a/Mb3Cpf1 technology generated two deletions in the portion of the gene that encodes for the mature 3 and 5 miRNAs (the 3p and 5p regions). (J:342486)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mir10b Mutation: 2 strains or lines available

References

• Original: J:342486 Zogg H, et al., miR-10b-5p rescues leaky gut linked with gastrointestinal dysmotility and diabetes. United European Gastroenterol J. 2023 Oct;11(8):750-766
• All: 1 reference(s)