Dram2^em1Jean
Endonuclease-mediated Allele Detail

Summary

• Symbol: Dram2^em1Jean
• Name: DNA-damage regulated autophagy modulator 2; endonuclease-mediated mutation 1, Marion Jeanne
• MGI ID: MGI:7564405
• Synonyms: Dram2^tm1Jean
• Gene: Dram2 Location: Chr3:106455114-106482657 bp, + strand Genetic Position: Chr3, 46.5 cM, cytoband F3
• Alliance: Dram2^em1Jean page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 technology generated a 585 bp deletion of exon 4 using sgRNAs 5-AGCATACTGTTAGCAAATCA and 5- TTATCTAAACCTAAGTTGCA. (J:341125)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dram2 Mutation: 23 strains or lines available

References

• Original: J:341125 Jones MK, et al., Integration of human stem cell-derived in vitro systems and mouse preclinical models identifies complex pathophysiologic mechanisms in retinal dystrophy. Front Cell Dev Biol. 2023;11:1252547
• All: 1 reference(s)