Apptm1.1(APP)Mdk
Targeted Allele Detail
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Symbol: |
Apptm1.1(APP)Mdk |
Name: |
amyloid beta precursor protein; targeted mutation 1.1, Michael D Koob |
MGI ID: |
MGI:7565473 |
Synonyms: |
APP-GR |
Gene: |
App Location: Chr16:84751236-84972187 bp, - strand Genetic Position: Chr16, 46.92 cM, cytoband C3-qter
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Alliance: |
Apptm1.1(APP)Mdk page
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Germline Transmission: |
Earliest citation of germline transmission:
J:347607
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Parent Cell Line: |
PRX-B6N (ES Cell)
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Strain of Origin: |
C57BL/6NTac
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Allele Type: |
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Targeted (Humanized sequence, Inserted expressed sequence) |
Mutations: |
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Insertion, Intragenic deletion
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Apptm1.1(APP)Mdk involves 1 genes/genome features (App)
View all
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Apptm1.1(APP)Mdk expresses
1 gene
Knock-in expresses:
Organism |
Expressed Gene |
Homolog in Mouse |
Note |
human |
APP (351) |
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Mutation details: The targeting vector is designed to insert a 343 kb (Chr21:25880264 - 26224036) fragment of the human APP (apolipoprotein) in place of 268 kb (Chr16:84750107 - 85019011) of the mouse App gene. The construct includes an FRT-flanked neomycin selection cassette. In addition, there is also a APP-DT (non-coding antisense RNA) in the human genome segment. The insertion disrupts App transcription.The neomycin cassette was removed by transient expression of cre.
(J:101977, J:347607)
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Original: |
J:101977 The Jackson Laboratory, Information obtained from The Jackson Laboratory, Bar Harbor, ME. Unpublished. 2005-2017; |
All: |
2 reference(s) |
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