Mir501^tm1Rchen
Targeted Allele Detail

Summary

• Symbol: Mir501^tm1Rchen
• Name: microRNA 501; targeted mutation 1, Rongqing Chen
• MGI ID: MGI:7567435
• Synonyms: Mir501^fx
• Gene: Mir501 Location: ChrX:7107482-7107590 bp, - strand Genetic Position: ChrX, 3.25 cM
• Alliance: Mir501^tm1Rchen page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:343467
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, Hypomorph)
• Mutation: Insertion
• Mutation details: The coding sequence was inverted and flanked with a pair of loxP sites and a pair of lox2722 sites via homologous recombination. Decreased expression in hemizygous and homozygous mice was confirmed by qRT-PCR. Expression of Clnc5 or the four nearby miRNAs was not reduced. Cre-mediated recombination will invert the coding sequence and restore expression. (J:343467)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mir501 Mutation: 1 strain or line available

References

• Original: J:343467 Liang W, et al., Loss of schizophrenia-related miR-501-3p in mice impairs sociability and memory by enhancing mGluR5-mediated glutamatergic transmission. Sci Adv. 2022 Aug 19;8(33):eabn7357
• All: 1 reference(s)