Tm4sf19^em1Sjkm
Endonuclease-mediated Allele Detail

Summary

• Symbol: Tm4sf19^em1Sjkm
• Name: transmembrane 4 L six family member 19; endonuclease-mediated mutation 1, Seong-Jin Kim
• MGI ID: MGI:7567663
• Synonyms: tm4sf19^-
• Gene: Tm4sf19 Location: Chr16:32219324-32227045 bp, + strand Genetic Position: Chr16, 22.66 cM
• Alliance: Tm4sf19^em1Sjkm page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 technology using sgRNAs 5-TGTCTTATACCACATCCCGT-3 and 5-GGCTAGTGAAGCGACTGTAC-3 targeting intron 1 and immediately downstream of the gene generated a knock-out allele. (J:343322)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tm4sf19 Mutation: 17 strains or lines available

References

• Original: J:343322 Park S, et al., Tm4sf19 deficiency inhibits osteoclast multinucleation and prevents bone loss. Metabolism. 2023 Nov 26;151:155746
• All: 1 reference(s)