Tm4sf19^em2Sjkm
Endonuclease-mediated Allele Detail

Summary

• Symbol: Tm4sf19^em2Sjkm
• Name: transmembrane 4 L six family member 19; endonuclease-mediated mutation 2, Seong-Jin Kim
• MGI ID: MGI:7567667
• Synonyms: LELdelta, tm4sf19 LEL^-
• Gene: Tm4sf19 Location: Chr16:32219324-32227045 bp, + strand Genetic Position: Chr16, 22.66 cM
• Alliance: Tm4sf19^em2Sjkm page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Not Applicable)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 technology using sgRNAs 5-TCTGGAGTAGCCTTGAAAGA-3 and 5-TGCCAAACCACAGCCTTAGA-3 targeting exon 4 and exon 5 deleted the large extracellular loop (LEL). (J:343322)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tm4sf19 Mutation: 17 strains or lines available

References

• Original: J:343322 Park S, et al., Tm4sf19 deficiency inhibits osteoclast multinucleation and prevents bone loss. Metabolism. 2023 Nov 26;151:155746
• All: 1 reference(s)