Lmx1b^em1(dre)Uze
Endonuclease-mediated Allele Detail

Summary

• Symbol: Lmx1b^em1(dre)Uze
• Name: LIM homeobox transcription factor 1 beta; endonuclease-mediated mutation 1, University of Zurich
• MGI ID: MGI:7567953
• Synonyms: Lmx1b^Dre
• Gene: Lmx1b Location: Chr2:33450977-33530620 bp, - strand Genetic Position: Chr2, 22.48 cM
• Alliance: Lmx1b^em1(dre)Uze page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Recombinase)
• Mutation: Insertion
• Lmx1b^em1(dre)Uze expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Lmx1b (MGI:1100513)

• Mutation details: CRISPR/cas9 genome editing used guide RNAs designed to insert a P2A self-cleaving peptide sequence (P2A) and a Dre recombinase sequence into the stop codon. (J:343535)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Lmx1b (mouse) Summary of all recombinase alleles driven by Lmx1b. Alliance mouse Lmx1b gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Lmx1b Mutation: 16 strains or lines available

References

• Original: J:343535 Frezel N, et al., c-Maf-positive spinal cord neurons are critical elements of a dorsal horn circuit for mechanical hypersensitivity in neuropathy. Cell Rep. 2023 Mar 21;42(4):112295
• All: 1 reference(s)