H2aj^em1Cmnn
Endonuclease-mediated Allele Detail

Summary

• Symbol: H2aj^em1Cmnn
• Name: H2J.A histone; endonuclease-mediated mutation 1, Carl Mann
• MGI ID: MGI:7567987
• Synonyms: H2AFJdelta7
• Gene: H2aj Location: Chr6:136785246-136787072 bp, + strand Genetic Position: Chr6, 66.72 cM
• Alliance: H2aj^em1Cmnn page

Mutation origin

• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: TALEN-mediated genome engineering introduced a 7 bp deletion, causing a frameshift with a premature stop codon at the start of the coding sequence. This disruption results in a truncated, non-functional protein product. Immunofluorescence microscopy showed no positive staining with an H2A.J antibody in the epidermis of 3- and 12-month-old and irradiated homozygous mutant mice. (J:343536)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any H2aj Mutation: 11 strains or lines available

References

• Original: J:343536 Rube CE, et al., Human skin aging is associated with increased expression of the histone variant H2A.J in the epidermis. NPJ Aging Mech Dis. 2021 Apr 1;7(1):7
• All: 1 reference(s)