Tnfaip8l1^em1Huwa
Endonuclease-mediated Allele Detail

Summary

• Symbol: Tnfaip8l1^em1Huwa
• Name: tumor necrosis factor, alpha-induced protein 8-like 1; endonuclease-mediated mutation 1, Hui Wang
• MGI ID: MGI:7567994
• Synonyms: Tipe1^-
• Gene: Tnfaip8l1 Location: Chr17:56469477-56480955 bp, + strand Genetic Position: Chr17, 29.19 cM, cytoband D
• Alliance: Tnfaip8l1^em1Huwa page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 technology generated a 181-bp deletion in exon 2. RT-PCR confirmed the absence of mRNA in splenocytes. (J:342074)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tnfaip8l1 Mutation: 12 strains or lines available

References

• Original: J:342074 Lou Y, et al., Epithelial TIPE1 Protein Guards against Colitis by Inhibiting TNF-alpha-Mediated Inflammation. J Immunol. 2023 Sep 1;211(5):874-884
• All: 1 reference(s)