Trim72^tm1Rpx
Targeted Allele Detail

Summary

• Symbol: Trim72^tm1Rpx
• Name: tripartite motif-containing 72; targeted mutation 1, Rui-Ping Xiao
• MGI ID: MGI:7568835
• Synonyms: MG53-C14A
• Gene: Trim72 Location: Chr7:127603121-127610205 bp, + strand Genetic Position: Chr7, 69.89 cM
• Alliance: Trim72^tm1Rpx page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:342778
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: Cysteine codon 14 (TGC) in exon 1 was changed to alanine (GCC) (p.C14A) and a loxP site flanked neomycin resistance gene cassette was inserted into intron 1. The mutation renders the encoded peptide ligase-dead. (J:342778)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Trim72 Mutation: 34 strains or lines available

References

• Original: J:342778 Feng H, et al., MG53 E3 Ligase-Dead Mutant Protects Diabetic Hearts From Acute Ischemic/Reperfusion Injury and Ameliorates Diet-Induced Cardiometabolic Damage. Diabetes. 2022 Feb 1;71(2):298-314
• All: 1 reference(s)