Etv6^em3Knic
Endonuclease-mediated Allele Detail

Summary

• Symbol: Etv6^em3Knic
• Name: ets variant 6; endonuclease-mediated mutation 3, Kim E Nichols
• MGI ID: MGI:7568839
• Synonyms: Etv6^R355X
• Gene: Etv6 Location: Chr6:134012663-134247121 bp, + strand Genetic Position: Chr6, 64.58 cM, cytoband G2
• Alliance: Etv6^em3Knic page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Humanized sequence, Null/knockout)
• Mutation: Single point mutation
• Mutation details: Arginine codon 355 (CGA) in exon 6 was changed to a stop codon (TGA) (p.R355*) using an sgRNA and an ssODN template with CRISP/Cas9 technology. The mutation is the equivalent of the human p.R359* mutation associated with thrombocytopenia 5 (T5). (J:342774)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Etv6 Mutation: 144 strains or lines available

References

• Original: J:342774 Bloom M, et al., ETV6 represses inflammatory response genes and regulates HSPC function during stress hematopoiesis in mice. Blood Adv. 2023 Sep 26;7(18):5608-5623
• All: 1 reference(s)