Hprt1tm6(CAG-Dll1/Dll4,-DsRed)Gos
Targeted Allele Detail
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Symbol: |
Hprt1tm6(CAG-Dll1/Dll4,-DsRed)Gos |
Name: |
hypoxanthine phosphoribosyltransferase 1; targeted mutation 6, Achim Gossler |
MGI ID: |
MGI:7571319 |
Synonyms: |
HprtDll1ECD_Dll4ICD |
Gene: |
Hprt1 Location: ChrX:52077014-52110536 bp, + strand Genetic Position: ChrX, 29.31 cM, cytoband A6
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Alliance: |
Hprt1tm6(CAG-Dll1/Dll4,-DsRed)Gos page
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Germline Transmission: |
Earliest citation of germline transmission:
J:274018
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Parent Cell Line: |
E14TG2a (ES Cell)
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Strain of Origin: |
129P2/OlaHsd
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Allele Type: |
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Targeted (Conditional ready, Inserted expressed sequence, Reporter) |
Mutation: |
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Insertion
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Mutation details: The targeting construct introduced into the locus an inverted CAG promoter driving expression of s fusion protein containing the extracellular domains of Dll1 and the intracellular domain of Dll4 followed by an IRES and DsRed reporter gene. Cre-mediated recombination is required to achieve expression.
(J:274018)
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Original: |
J:274018 Tveriakhina L, et al., The ectodomains determine ligand function in vivo and selectivity of DLL1 and DLL4 toward NOTCH1 and NOTCH2 in vitro. Elife. 2018 Oct 5;7:e40045 |
All: |
1 reference(s) |
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